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Dermal Substitute

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Evolution of Dermal Substitute

Adequate soft-tissue coverage prior to excision of burned tissue is necessary in order to counteract the physiologic, metabolic and psychologic costs associated with burns. Early excision of burned tissue is the key factor in achieving optimal patient outcomes following a burn. Extensive burns often render little tissue available for graft donation, or patient factors may serve as a barrier to skin grafting. Dermal substitutes can act as a scaffold upon which eventual skin grafts can be placed. They serve to improve functional results in the acute phase of thermal injuries, and provide a matrix upon which dermis can be regenerated. Various sources of dermal allograft have been identified.

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