Botox Chemical Denervation

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Evolution of Botox Chemical Denervation

Botox, aka Onabotulinumtoxin A, is an example of a chemical compound used in selective denervation. It is isolated from the naturally occurring neurotoxin Clostridium botulinum. The mechanism of its action is via prevention of the release of the neurotransmitter acetylcholine at the presynaptic nerve terminal. In this way it effectively blocks neurotransmission from nerve to muscle or gland. This state can last for months, until certain components of the nerve are able to regenerate and again release acetylcholine at the presynaptic terminal.

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