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Incobotulinumtoxin A, is an additional chemical denervating compound that has the same mechanism of action as Botox. Since Xeomin does not have some of the additive proteins that Botox does, long-term users that have developed resistance to Botox may still be treatable with Xeomin. Traditionally, those who stop responding to Botox after repetitive treatments may consider a trail of Xeomin.

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