The use of botulinum toxin on humans was pioneered in the 1980s. It’s use to treat wrinkles, rhytids, is...
BOTOX is derived from the toxin of the Clostridium Botulinum bacteria and results in muscle paralysis at the site of injection. It was initially approved in the United States for injection in 1989. It is the most common cosmetic procedure performed in the United States. In addition to cosmetic applications, it is also approved to treat conditions such as muscle spasticity, overactive bladder, and migraine headache. It is packaged in a vacuum dried vial containing the toxin, and must be mixed with a small amount of saline before injection.
For treatment of wrinkles, a small syringe is used along with a very fine needle. BOTOX is then injected into the muscle underlaying the wrinkles, typically the frontalis (forehead), procerus and corregators (frown lines), and/ or the orbicularis oculi (crows feet). Multiple areas may be treated at the same time. There is minimal pain or bruising with the procedure. Afterwards, full effect will be seen in about 7 days and will last for 3-6 months. Most effect will be seen on dynamic wrinkles, though there is typically improvement in deep, static wrinkles as well.