Botox, aka Onabotulinumtoxin A, is an example of a chemical compound used in selective denervation. It is isolated from...
Evolution of Selective Denervation
Selective denervation refers to the providers ability to select which neuron they would like to deem non functional. This may be done in cases of facial muscle asymmetry after facial paralysis, or more commonly with Botox injections for facial “wrinkles”, or rhytids. Two ways of performing selective denervation are with mechanical, or “cold knife” excision, and chemically with injectable material. Cold knife denervation consists of a surgeon isolating a nerve (commonly with the innervated muscle) and selectively severing it without damaging surrounding structures. This should deem the innervated muscle paralyzed.